Publications & Speaking

Our science, based on trusted and peer-reviewed literature, drives the field forward.

Academic Use of Aetion

The Aetion Evidence Platform is used by leading academics worldwide in their peer-reviewed research. The platform is also used in database analytics and comparative effectiveness courses taken by epidemiologists, outcomes researchers, health economists and biostatisticians. Courses are offered both at Harvard and in Europe.  For custom courses designed for your organization, please contact us.

Selected Publications

Below is a selection of peer-reviewed publications using Aetion Evidence Platform analytics. 

Cheng F, Desai RJ, Handy DE, Wang R, Schneeweiss S, Barabási AL, Loscalzo J. Network-based approach to prediction and population-based validation of in silico drug repurposing. Nature Comm. 2018;9:2691. doi: 10.1038/s41467-018-05116-5.

Kim SC, Solomon DH, Rogers JR, Gale S, Klearman M, Sarsour K, Schneeweiss S. No difference in cardiovascular risk of tocilizumab versus abatacept for rheumatoid arthritis: A multi-database cohort study. Semin Arthritis Rheum. 2018 Mar 22. pii: S0049-0172(17)30810-7. doi: 10.1016/j.semarthrit.2018.03.012. [Epub ahead of print]

Fralick M, Schneeweiss S, Patorno E. Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor. N Engl J Med. 2017;376(23):2300-2302. doi:10.1056/NEJMc1701990.

Kim SC, Solomon DH, Rogers JR, et al. Cardiovascular Safety of Tocilizumab versus Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis - a Multi-database Cohort Study. Arthritis Rheumatol. February 2017. doi:10.1002/art.40084.

Wang SV, Verpillat P, Rassen JA, Patrick A, Garry EM, Bartels DB. Transparency and Reproducibility of Observational Cohort Studies Using Large Healthcare Databases. Clinical Pharmacology & Therapeutics. 2016;99(3):325-332. doi:10.1002/cpt.329.

Coleman CI, Antz M, Bowrin K, et al. Real-world evidence of stroke prevention in patients with nonvalvular atrial fibrillation in the United States: the REVISIT-US study. Curr Med Res Opin. 2016;32(12):2047-2053. doi:10.1080/03007995.2016.1237937.

Nakasian SS, Rassen JA, Franklin JM. Effects of expanding the look-back period to all available data in the assessment of covariates. Pharmacoepidem Drug Safe. 2017;19(8):858–10. doi:10.1002/pds.4210.

Simard EP, Ruehmkorf F, Hawes JCL, Verpillat P.  Can Rheumatoid Arthritis Associated With Interstitial Lung Disease (RA-ILD) Be Classified As An Orphan Disease In The U.S.?  31st ICPE, Boston, MA.

Selected Publications by the Aetion Team

Aetion team members publish frequently on real-world data methodological topics and applications. Below you will find a short list of publications; a full list is available here.

Schneeweiss S. A basic study design for expedited safety signal evaluation based on electronic healthcare data. Pharmaceopidemiol Drug Safety 2010;19:858-68.

Schneeweiss S. Learning from big healthcare data. N Engl J Med 2014;370:2161-3.

Schneeweiss S, Gagne JJ, Glynn RJ, Ruhl M, Rassen JA. Assessing the comparative effectiveness
of newly marketed medications. Clin Pharm Ther 2011;90:777-90.

Schneeweiss S, Rassen JA, Glynn RJ, Avorn J, Mogun H, Brookhart MA. High-dimensional propensity score adjustment in studies of treatment effects using health care claims data. Epidemiology 2009;20:512-22. 

Rassen JA, Shelat AA, Myers J, Glynn RJ, Rothman KJ, Schneeweiss S. One-to-many propensity score matching in cohort studies. Pharmacoepidemiol Drug Saf 2012;21(S2):69-80.

Franklin JM, Rassen JA, Ackermann D, Bartels DB, Schneeweiss S. Metrics for covariate balance in cohort studies of causal effects: Varying associations with bias. Stat Med 2014;33:1685-99. 

Neugebauer R, Schmittdiel JA, Zhu Z, Rassen JA, Seeger JD, Schneeweiss S. High-dimensional propensity score algorithm in comparative effectiveness research with time-varying interventions. Stat Med 2014;34:753-81.

Schneeweiss S, Eddings W, Glynn RJ, Patorno E, Rassen JA, Franklin JM. Variable selection for confounding adjustment in high-dimensional covariate spaces when analyzing healthcare databases. Epidemiology 2017;28:237-48.

Speaking Calendar

Big Data: Transforming Global Health Care
Carolyn Magill, M.B.A.
Fortune Global Forum 2018
Toronto, Canada
October 16, 2018
Goldman Sachs Builders + Innovators Summit 2018
Carolyn Magill, M.B.A.
Santa Barbara, CA
October 17, 2018
How Real-World Evidence Can Improve Clinical Trial Productivity
Jeremy Rassen, Sc.D.
BIO Investor Forum
San Francisco, California
October 18, 2018
Value-based pharmaceutical care
Jeremy Rassen, Sc.D.
20 years of DoPE
Boston, MA
October 23, 2018
Effective use of Real World Data Analytics across the Life Cycle: Data, Analytics, People, Organizations
Sebastian Schneeweiss, M.D., Sc.D.
Real-World Insights & Life Science Analytics Congress
Boston, MA
October 25, 2018
Bringing two worlds together
Sara Eapen, Ph.D.
Real-World Insights & Life Science Analytics Congress
Boston, MA
October 25, 2018
Real world evidence or clinical trials? Which should I believe?
Jeremy Rassen, Sc.D.
ACPE 2018
Xi-an China
October 28, 2018
Non-Interventional Studies: Study Design Considerations and Current Applications
Sebastian Schneeweiss, M.D., Sc.D.
Real World Evidence Conference
San Francisco, CA
November 5, 2018
Oliver Wyman Health Innovation Summit 2018
Selvam Velmurugan, M.S.
Dallas, Texas
November 5, 2018
Pharmacoepidemiology for regulatory decision making and the importance of analytic platforms
Sebastian Schneeweiss, M.D., Sc.D.
Annual CNODES Meeting
Montreal, Canada
November 7, 2018
The future of pharma requires a value shift
Scott Musial, M.S. Pharmacy
8th Annual eyeforpharma Value Summit
Philadelphia, PA
November 7, 2018
Use of Propensity Scores in Observational Studies of Treatment Effects
Jeremy Rassen, Sc.D.
ISPOR Europe 2018
Barcelona, Spain
November 10, 2018
Addressing Challenges to Open Science: Data sharing, replication, and robustness of evidence from real world data
Sebastian Schneeweiss, M.D., Sc.D.
ISPOR Europe 2018
Barcelona, Spain
November 14, 2018
Next Steps for Value-Based Care
Carolyn Magill, M.B.A.
U.S. News Healthcare of Tomorrow 2018
Washington, DC
November 15, 2018
Evidences of Access Impact: Conclusions from the Satellite Workshop
Sebastian Schneeweiss, M.D., Sc.D.
2nd Symposium on Accessibility and Impact of High Value Medicines
London, UK
January 16, 2019
Generating RWE Fit for Regulatory Decisions: Learning from Safety
Sebastian Schneeweiss, M.D., Sc.D.
Pharmacovigilance and Risk Management Strategies Conference
Washington, DC
January 29, 2019
Automated data adaptive analytics for electronic healthcare data to study causal treatment effects
Sebastian Schneeweiss, M.D., Sc.D.
Danish Epidemiology Society, University of Copenhagen
Copenhagen, Denmark
April 9, 2019
Comparative Effectiveness Research
Sebastian Schneeweiss, M.D., Sc.D.
35th ICPE
Philadelphia, PA
August 24, 2019
Applied sensitivity analyses
Sebastian Schneeweiss, M.D., Sc.D.
35th ICPE
Philadelphia, PA
August 24, 2019

Selected Past Events

Transforming big, real-world data for decision-making about medical treatments
Jeremy Rassen, Sc.D.
CFDA China Center for Food & Drug International Exchange Conference
January 21, 2018
Developing Real World Evidence Fit for Regulatory Decision Making
Sebastian Schneeweiss, M.D., Sc.D.
American Journal of Law & Medicine Symposium
January 26, 2018
Using Complex Healthcare Databases to Evaluate the Safety and Effectiveness of Newly Marketed Medications
Sebastian Schneeweiss, M.D., Sc.D.
ASCPT 2018
March 24, 2018
Workshop on the Regulatory Applications of Observational Studies
Sebastian Schneeweiss, M.D., Sc.D.
Duke Margolis Center
March 29, 2018
Workshop on Real-World Data Quality
Sebastian Schneeweiss, M.D., Sc.D.
Duke Margolis Center
April 26, 2018
Examination of Supplemental Indication in Cardiology Using Real World Data
Sebastian Schneeweiss, M.D., Sc.D.
2018 Accelerating Anticancer Agent Development and Validation (AAADV) Workshop
May 3, 2018
Big Data for Pharmacovigilance
Jeremy Rassen, Sc.D.
Drug Safety Research Unit
June 20, 2018
Real world data analyses for regulatory decision making - a global opportunity
Sebastian Schneeweiss, M.D., Sc.D.
Karolinska Institutet
June 29, 2018
Propensity Scores in Pharmacoepidemiology
Jeremy Rassen, Sc.D.
ICPE
August 23, 2018
Advanced Topics in PE: Healthcare database analyses for regulatory decision making
Sebastian Schneeweiss, M.D., Sc.D.
ICPE
August 23, 2018
Applied Sensitivity Analyses in Pharmacoepidemiology Database Studies
Sebastian Schneeweiss, M.D., Sc.D.
ICPE
August 24, 2018
Data-adaptive Methods for Causal Inference, Automation, and the Rise of Analytic Platforms in Pharmacoepidemiology
Sebastian Schneeweiss, M.D., Sc.D.
University of Bordeaux
September 13, 2018
One Size Does Not Fit All: Advances in Precision Health and Medicine
Scott Musial, M.S. Pharmacy
Health 2.0
September 18, 2018